Ontology highlight
ABSTRACT:
SUBMITTER: Henne WM
PROVIDER: S-EPMC2883440 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20100506 5983
Clathrin-mediated endocytosis, the major pathway for ligand internalization into eukaryotic cells, is thought to be initiated by the clustering of clathrin and adaptors around receptors destined for internalization. However, here we report that the membrane-sculpting F-BAR domain-containing Fer/Cip4 homology domain-only proteins 1 and 2 (FCHo1/2) were required for plasma membrane clathrin-coated vesicle (CCV) budding and marked sites of CCV formation. Changes in FCHo1/2 expression levels correla ...[more]