Ontology highlight
ABSTRACT:
SUBMITTER: Gunasekaran K
PROVIDER: S-EPMC2885242 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Gunasekaran Kannan K Pentony Martin M Shen Min M Garrett Logan L Forte Carla C Woodward Anne A Ng Soo Bin SB Born Teresa T Retter Marc M Manchulenko Kathy K Sweet Heather H Foltz Ian N IN Wittekind Michael M Yan Wei W
The Journal of biological chemistry 20100416 25
Naturally occurring IgG antibodies are bivalent and monospecific. Bispecific antibodies having binding specificities for two different antigens can be produced using recombinant technologies and are projected to have broad clinical applications. However, co-expression of multiple light and heavy chains often leads to contaminants and pose purification challenges. In this work, we have modified the CH3 domain interface of the antibody Fc region with selected mutations so that the engineered Fc pr ...[more]