Ontology highlight
ABSTRACT:
SUBMITTER: Shan L
PROVIDER: S-EPMC8426389 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Shan Lu L Dyk Nydia Van NV Haskins Nantaporn N Cook Kimberly M KM Rosenthal Kim L KL Mazor Ronit R Dragulin-Otto Sonia S Jiang Yu Y Wu Herren H Dall'Acqua William F WF Borrok Martin J MJ Damschroder Melissa M MM Oganesyan Vaheh V
Communications biology 20210908 1
In a biologic therapeutic landscape that requires versatility in targeting specificity, valency and half-life modulation, the monomeric Fc fusion platform holds exciting potential for the creation of a class of monovalent protein therapeutics that includes fusion proteins and bispecific targeting molecules. Here we report a structure-guided approach to engineer monomeric Fc molecules to adapt multiple versions of half-life extension modifications. Co-crystal structures of these monomeric Fc vari ...[more]