Ontology highlight
ABSTRACT:
SUBMITTER: Gamblin CL
PROVIDER: S-EPMC3926957 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Gamblin Clémence L CL Hardy Émilie J-L ÉJ Chartier François J-M FJ Bisson Nicolas N Laprise Patrick P
The Journal of cell biology 20140210 4
During epithelial cell polarization, Yurt (Yrt) is initially confined to the lateral membrane and supports the stability of this membrane domain by repressing the Crumbs-containing apical machinery. At late stages of embryogenesis, the apical recruitment of Yrt restricts the size of the apical membrane. However, the molecular basis sustaining the spatiotemporal dynamics of Yrt remains undefined. In this paper, we report that atypical protein kinase C (aPKC) phosphorylates Yrt to prevent its prem ...[more]