Ontology highlight
ABSTRACT:
SUBMITTER: Tam C
PROVIDER: S-EPMC2886342 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Tam Christina C Idone Vincent V Devlin Cecilia C Fernandes Maria Cecilia MC Flannery Andrew A He Xingxuan X Schuchman Edward E Tabas Ira I Andrews Norma W NW
The Journal of cell biology 20100607 6
Rapid plasma membrane resealing is essential for cellular survival. Earlier studies showed that plasma membrane repair requires Ca(2+)-dependent exocytosis of lysosomes and a rapid form of endocytosis that removes membrane lesions. However, the functional relationship between lysosomal exocytosis and the rapid endocytosis that follows membrane injury is unknown. In this study, we show that the lysosomal enzyme acid sphingomyelinase (ASM) is released extracellularly when cells are wounded in the ...[more]