Ontology highlight
ABSTRACT:
SUBMITTER: Idone V
PROVIDER: S-EPMC2265401 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Idone Vincent V Tam Christina C Goss John W JW Toomre Derek D Pypaert Marc M Andrews Norma W NW
The Journal of cell biology 20080303 5
Ca2+ influx through plasma membrane lesions triggers a rapid repair process that was previously shown to require the exocytosis of lysosomal organelles (Reddy, A., E. Caler, and N. Andrews. 2001. Cell. 106:157-169). However, how exocytosis leads to membrane resealing has remained obscure, particularly for stable lesions caused by pore-forming proteins. In this study, we show that Ca2+-dependent resealing after permeabilization with the bacterial toxin streptolysin O (SLO) requires endocytosis vi ...[more]