Ontology highlight
ABSTRACT:
SUBMITTER: von Kampen O
PROVIDER: S-EPMC2888403 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
von Kampen Oliver O Lipinski Simone S Till Andreas A Martin Seamus J SJ Nietfeld Wilfried W Lehrach Hans H Schreiber Stefan S Rosenstiel Philip P
The Journal of biological chemistry 20100412 26
Caspase activating and recruitment domain 8 (CARD8) has been implicated as a co-regulator of several pro-inflammatory and apoptotic signaling pathways. In the present study, we demonstrate a specific modulation of NOD2-induced signaling by CARD8 in intestinal epithelial cells. We show that CARD8 physically interacts with NOD2 and inhibits nodosome assembly and subsequent signaling upon muramyl-dipeptide stimulation. Furthermore, CARD8 inhibits the direct bactericidal effect of NOD2 against intra ...[more]