Ontology highlight
ABSTRACT:
SUBMITTER: Cilibrizzi A
PROVIDER: S-EPMC2888720 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20090801 16
Following a ligand-based drug design approach, a potent mixed formyl peptide receptor 1 (FPR1) and formyl peptide receptor-like 1 (FPRL1) agonist (14a) and a potent and specific FPRL1 agonist (14x) were identified. These compounds belong to a large series of pyridazin-3(2H)-one derivatives substituted with a methyl group at position 6 and a methoxy benzyl at position 4. At position 2, an acetamide side chain is essential for activity. Likewise, the presence of lipophilic and/or electronegative s ...[more]