Ontology highlight
ABSTRACT:
SUBMITTER: Bachstetter AD
PROVIDER: S-EPMC2889032 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Neurobiology of aging 20091216 11
Microglia have neuroprotective capacities, yet chronic activation can promote neurotoxic inflammation. Neuronal fractalkine (FKN), acting on CX(3)CR1, has been shown to suppress excessive microglia activation. We found that disruption in FKN/CX(3)CR1 signaling in young adult rodents decreased survival and proliferation of neural progenitor cells through IL-1β. Aged rats were found to have decreased levels of hippocampal FKN protein; moreover, interruption of CX(3)CR1 function in these animals di ...[more]