Ontology highlight
ABSTRACT:
SUBMITTER: Ostroff LE
PROVIDER: S-EPMC2889073 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Ostroff Linnaea E LE Cain Christopher K CK Bedont Joseph J Monfils Marie H MH Ledoux Joseph E JE
Proceedings of the National Academy of Sciences of the United States of America 20100503 20
Fear learning is associated with changes in synapse strength in the lateral amygdala (LA). To examine changes in LA dendritic spine structure with learning, we used serial electron microscopy to re-construct dendrites after either fear or safety conditioning. The spine apparatus, a smooth endoplasmic reticulum (sER) specialization found in very large spines, appeared more frequently after fear conditioning. Fear conditioning was associated with larger synapses on spines that did not contain a sp ...[more]