Ontology highlight
ABSTRACT:
SUBMITTER: Kuroda Y
PROVIDER: S-EPMC2889306 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Kuroda Yasumasa Y Kitada Masaaki M Wakao Shohei S Nishikawa Kouki K Tanimura Yukihiro Y Makinoshima Hideki H Goda Makoto M Akashi Hideo H Inutsuka Ayumu A Niwa Akira A Shigemoto Taeko T Nabeshima Yoko Y Nakahata Tatsutoshi T Nabeshima Yo-Ichi Y Fujiyoshi Yoshinori Y Dezawa Mari M
Proceedings of the National Academy of Sciences of the United States of America 20100426 19
We found adult human stem cells that can generate, from a single cell, cells with the characteristics of the three germ layers. The cells are stress-tolerant and can be isolated from cultured skin fibroblasts or bone marrow stromal cells, or directly from bone marrow aspirates. These cells can self-renew; form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency; and can differentiate into endodermal, ectodermal, and mesodermal cells both in ...[more]