Ontology highlight
ABSTRACT:
SUBMITTER: Mudrak B
PROVIDER: S-EPMC3153253 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Enterotoxigenic Escherichia coli (ETEC) is a significant source of morbidity and mortality worldwide. One major virulence factor released by ETEC is the heat-labile enterotoxin LT, which is structurally and functionally similar to cholera toxin. LT consists of five B subunits carrying a single catalytically active A subunit. LTB binds the monosialoganglioside G(M1), the toxin's host receptor, but interactions with A-type blood sugars and E. coli lipopolysaccharide have also been identified withi ...[more]