Ontology highlight
ABSTRACT:
SUBMITTER: Coleman HA
PROVIDER: S-EPMC2889607 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Coleman Hope A HA Labrador Juan-Pablo JP Chance Rebecca K RK Bashaw Greg J GJ
Development (Cambridge, England) 20100701 14
Slits and their Roundabout (Robo) receptors mediate repulsive axon guidance at the Drosophila ventral midline and in the vertebrate spinal cord. Slit is cleaved to produce fragments with distinct signaling properties. In a screen for genes involved in Slit-Robo repulsion, we have identified the Adam family metalloprotease Kuzbanian (Kuz). Kuz does not regulate midline repulsion through cleavage of Slit, nor is Slit cleavage essential for repulsion. Instead, Kuz acts in neurons to regulate repuls ...[more]