Ontology highlight
ABSTRACT:
SUBMITTER: Kellermeyer R
PROVIDER: S-EPMC7648596 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Kellermeyer Riley R Heydman Leah M LM Gillis Taylor T Mastick Grant S GS Song Minmin M Kidd Thomas T
Development (Cambridge, England) 20201029 20
Slit is a secreted protein that has a canonical function of repelling growing axons from the CNS midline. The full-length Slit (Slit-FL) is cleaved into Slit-N and Slit-C fragments, which have potentially distinct functions via different receptors. Here, we report that the BMP-1/Tolloid family metalloprotease Tolkin (Tok) is responsible for Slit proteolysis <i>in vivo</i> and <i>in vitro.</i> In <i>Drosophila</i><i>tok</i> mutants lacking Slit cleavage, midline repulsion of axons occurs normally ...[more]