Ontology highlight
ABSTRACT:
SUBMITTER: Grabundzija I
PROVIDER: S-EPMC2889740 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Grabundzija Ivana I Irgang Markus M Mátés Lajos L Belay Eyayu E Matrai Janka J Gogol-Döring Andreas A Kawakami Koichi K Chen Wei W Ruiz Patricia P Chuah Marinee K L MK VandenDriessche Thierry T Izsvák Zsuzsanna Z Ivics Zoltán Z
Molecular therapy : the journal of the American Society of Gene Therapy 20100406 6
Transposon-based gene vectors have become indispensable tools in vertebrate genetics for applications ranging from insertional mutagenesis and transgenesis in model species to gene therapy in humans. The transposon toolkit is expanding, but a careful, side-by-side characterization of the diverse transposon systems has been lacking. Here we compared the Sleeping Beauty (SB), piggyBac (PB), and Tol2 transposons with respect to overall activity, overproduction inhibition (OPI), target site selectio ...[more]