Ontology highlight
ABSTRACT:
SUBMITTER: Rieder U
PROVIDER: S-EPMC2890745 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Rieder Ulrike U Kreutz Christoph C Micura Ronald R
Proceedings of the National Academy of Sciences of the United States of America 20100601 24
7-Aminomethyl-7-deazaguanine (preQ(1)) sensitive mRNA domains belong to the smallest riboswitches known to date. Although recent efforts have revealed the three-dimensional architecture of the ligand-aptamer complex less is known about the molecular details of the ligand-induced response mechanism that modulates gene expression. We present an in vitro investigation on the ligand-induced folding process of the preQ(1) responsive RNA element from Fusobacterium nucleatum using biophysical methods, ...[more]