Ontology highlight
ABSTRACT:
SUBMITTER: Gong Z
PROVIDER: S-EPMC3963873 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Gong Zhou Z Zhao Yunjie Y Chen Changjun C Duan Yong Y Xiao Yi Y
PloS one 20140324 3
Riboswitches play roles in transcriptional or translational regulation through specific ligand binding of their aptamer domains. Although a number of ligand-bound aptamer complex structures have been solved, it is important to know ligand-free conformations of the aptamers in order to understand the mechanism of specific binding by ligands. In this paper, preQ1 riboswitch aptamer domain from Bacillus subtilis is studied by overall 1.5 μs all-atom molecular dynamics simulations We found that the ...[more]