Ontology highlight
ABSTRACT:
SUBMITTER: Liberman JA
PROVIDER: S-EPMC3661761 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Liberman Joseph A JA Salim Mohammad M Krucinska Jolanta J Wedekind Joseph E JE
Nature chemical biology 20130414 6
PreQ1 riboswitches regulate genes by binding the pyrrolopyrimidine intermediate preQ1 during the biosynthesis of the essential tRNA base queuosine. We report what is to our knowledge the first preQ1-II riboswitch structure at 2.3-Å resolution, which uses a previously uncharacterized fold to achieve effector recognition at the confluence of a three-way helical junction flanking a pseudoknotted ribosome-binding site. The results account for translational control mediated by the preQ1-II riboswitch ...[more]