Ontology highlight
ABSTRACT:
SUBMITTER: Dekanty A
PROVIDER: S-EPMC2891703 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Dekanty Andrés A Romero Nuria M NM Bertolin Agustina P AP Thomas María G MG Leishman Claudia C CC Perez-Perri Joel I JI Boccaccio Graciela L GL Wappner Pablo P
PLoS genetics 20100624 6
Hypoxia-inducible factors (HIFs) are a family of evolutionary conserved alpha-beta heterodimeric transcription factors that induce a wide range of genes in response to low oxygen tension. Molecular mechanisms that mediate oxygen-dependent HIF regulation operate at the level of the alpha subunit, controlling protein stability, subcellular localization, and transcriptional coactivator recruitment. We have conducted an unbiased genome-wide RNA interference (RNAi) screen in Drosophila cells aimed to ...[more]