Ontology highlight
ABSTRACT:
SUBMITTER: Aikin R
PROVIDER: S-EPMC3303847 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Aikin Reid R Cervantes Alexandra A D'Angelo Gisela G Ruel Laurent L Lacas-Gervais Sandra S Schaub Sébastien S Thérond Pascal P
PloS one 20120314 3
Hedgehog (Hh) proteins are secreted molecules that function as organizers in animal development. In addition to being palmitoylated, Hh is the only metazoan protein known to possess a covalently-linked cholesterol moiety. The absence of either modification severely disrupts the organization of numerous tissues during development. It is currently not known how lipid-modified Hh is secreted and released from producing cells. We have performed a genome-wide RNAi screen in Drosophila melanogaster ce ...[more]