Ontology highlight
ABSTRACT:
SUBMITTER: Zeng X
PROVIDER: S-EPMC4420031 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Zeng Xiankun X Han Lili L Singh Shree Ram SR Liu Hanhan H Neumüller Ralph A RA Yan Dong D Hu Yanhui Y Liu Ying Y Liu Wei W Lin Xinhua X Hou Steven X SX
Cell reports 20150219 7
The intestinal epithelium is the most rapidly self-renewing tissue in adult animals and maintained by intestinal stem cells (ISCs) in both Drosophila and mammals. To comprehensively identify genes and pathways that regulate ISC fates, we performed a genome-wide transgenic RNAi screen in adult Drosophila intestine and identified 405 genes that regulate ISC maintenance and lineage-specific differentiation. By integrating these genes into publicly available interaction databases, we further develop ...[more]