Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC2892195 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Zhang Yuehua Y Thomas Thommey P TP Desai Ankur A Zong Hong H Leroueil Pascale R PR Majoros Istvan J IJ Baker James R JR
Bioconjugate chemistry 20100203 3
A targeted dendrimeric anticancer prodrug, a conjugate of generation 5 (G5) polyamidoamine (PAMAM) dendrimer, folic acid (FA), and methotrexate (MTX), has been successfully synthesized by using a novel "one pot" approach which is simple, reproducible, and feasible for large-scale synthesis. All dendrimer products have been characterized by (1)H NMR, MALDI-TOF, GPC, and HPLC. With this new method, the ratio of FA versus MTX attached to the dendrimer can be easily tuned to achieve the desired ther ...[more]