Ontology highlight
ABSTRACT:
SUBMITTER: Airola MV
PROVIDER: S-EPMC2892831 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Airola Michael V MV Watts Kylie J KJ Bilwes Alexandrine M AM Crane Brian R BR
Structure (London, England : 1993) 20100301 4
HAMP domains are widespread prokaryotic signaling modules found as single domains or poly-HAMP chains in both transmembrane and soluble proteins. The crystal structure of a three-unit poly-HAMP chain from the Pseudomonas aeruginosa soluble receptor Aer2 defines a universal parallel four-helix bundle architecture for diverse HAMP domains. Two contiguous domains integrate to form a concatenated di-HAMP structure. The three HAMP domains display two distinct conformations that differ by changes in h ...[more]