Ontology highlight
ABSTRACT:
SUBMITTER: Gong W
PROVIDER: S-EPMC28016 | biostudies-literature | 1998 Dec
REPOSITORIES: biostudies-literature
Gong W W Hao B B Mansy S S SS Gonzalez G G Gilles-Gonzalez M A MA Chan M K MK
Proceedings of the National Academy of Sciences of the United States of America 19981201 26
The FixL proteins are biological oxygen sensors that restrict the expression of specific genes to hypoxic conditions. FixL's oxygen-detecting domain is a heme binding region that controls the activity of an attached histidine kinase. The FixL switch is regulated by binding of oxygen and other strong-field ligands. In the absence of bound ligand, the heme domain permits kinase activity. In the presence of bound ligand, this domain turns off kinase activity. Comparison of the structures of two for ...[more]