Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC2893247 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Liu Yang Y Liu Rui R Mao Shui-Chun SC Morgan J Brian JB Jekabsons Mika B MB Zhou Yu-Dong YD Nagle Dale G DG
Journal of natural products 20081106 11
A natural product chemistry-based approach was employed to discover small-molecule inhibitors of the important tumor-selective molecular target hypoxia-inducible factor-1 (HIF-1). Bioassay-guided isolation of an active lipid extract of a Saipan collection of the marine sponge Lendenfeldia sp. afforded the terpene-derived furanolipid furospongolide as the primary inhibitor of hypoxia-induced HIF-1 activation (IC(50) 2.9 μM, T47D breast tumor cells). The active component of the extract also contai ...[more]