Ontology highlight
ABSTRACT:
SUBMITTER: Kamhi E
PROVIDER: S-EPMC2895067 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Kamhi Eyal E Raitskin Oleg O Sperling Ruth R Sperling Joseph J
Proceedings of the National Academy of Sciences of the United States of America 20100607 25
The translation initiator-tRNA plays a crucial role in the initiation of protein synthesis in both prokaryotic and eukaryotic cells, by employing specific base pairing between its anticodon triplet CAU and the general initiation codon AUG in the mRNA. Here we show that the initiator-tRNA may also act, in a manner that is independent of its role in protein translation, as a pre-mRNA splicing regulator. Specifically, we show that alternative splicing events that are induced by mutations in the tra ...[more]