Ontology highlight
ABSTRACT:
SUBMITTER: Kumar D
PROVIDER: S-EPMC2896522 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Kumar Dinesh D Viberg Jörgen J Nilsson Anna Karin AK Chabes Andrei A
Nucleic acids research 20100309 12
A balanced supply of deoxyribonucleoside triphosphates (dNTPs) is one of the key prerequisites for faithful genome duplication. Both the overall concentration and the balance among the individual dNTPs (dATP, dTTP, dGTP, and dCTP) are tightly regulated, primarily by the enzyme ribonucleotide reductase (RNR). We asked whether dNTP pool imbalances interfere with cell cycle progression and are detected by the S-phase checkpoint, a genome surveillance mechanism activated in response to DNA damage or ...[more]