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Synthesis and preliminary biological studies of 3-substituted indoles accessed by a palladium-catalyzed enantioselective alkene difunctionalization reaction.

ABSTRACT: A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The reaction proceeds with up to 87% yield, 99:1 er, and >20:1 dr. Evaluation of several of the compounds revealed promising anticancer activity against MCF-7 cells.

SUBMITTER: Pathak TP

PROVIDER: S-EPMC2896870 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Synthesis and preliminary biological studies of 3-substituted indoles accessed by a palladium-catalyzed enantioselective alkene difunctionalization reaction.

Pathak Tejas P TP Gligorich Keith M KM Welm Bryan E BE Sigman Matthew S MS

Journal of the American Chemical Society 20100601 23

A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The reaction proceeds with up to 87% yield, 99:1 er, and >20:1 dr. Evaluation of several of the compounds revealed promising anticancer activity against MCF-7 cells. ...[more]

PMID: 20486685

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