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Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions.

ABSTRACT: Highly substituted indoles were synthesized by a palladium-catalyzed reaction involving three independent components in a one-pot reaction. Two distinct palladium-catalyzed coupling reactions occur with a single catalytic system: a Buchwald-Hartwig reaction and an arene-alkene coupling. Quantum chemical computations provide insight into the mechanism of the latter coupling step.

SUBMITTER: Knapp JM

PROVIDER: S-EPMC3517165 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions.

Knapp John M JM Zhu Jie S JS Tantillo Dean J DJ Kurth Mark J MJ

Angewandte Chemie (International ed. in English) 20120924 42

Highly substituted indoles were synthesized by a palladium-catalyzed reaction involving three independent components in a one-pot reaction. Two distinct palladium-catalyzed coupling reactions occur with a single catalytic system: a Buchwald-Hartwig reaction and an arene-alkene coupling. Quantum chemical computations provide insight into the mechanism of the latter coupling step. ...[more]

PMID: 23001913

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