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Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation.

ABSTRACT: A central step to high fidelity protein synthesis is selection of the proper start codon. Recent structural, biochemical, and genetic analyses have provided molecular insights into the coordinated activities of the initiation factors in start codon selection. A molecular model is emerging in which start codon recognition is linked to dynamic reorganization of factors on the ribosome and structural changes in the ribosome itself.

SUBMITTER: Lorsch JR

PROVIDER: S-EPMC2898419 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation.

Lorsch Jon R JR Dever Thomas E TE

The Journal of biological chemistry 20100505 28

A central step to high fidelity protein synthesis is selection of the proper start codon. Recent structural, biochemical, and genetic analyses have provided molecular insights into the coordinated activities of the initiation factors in start codon selection. A molecular model is emerging in which start codon recognition is linked to dynamic reorganization of factors on the ribosome and structural changes in the ribosome itself. ...[more]

PMID: 20444698

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