Ontology highlight
ABSTRACT:
SUBMITTER: Hong Z
PROVIDER: S-EPMC2900252 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Hong Zhangyong Z Liu Lei L Sugiyama Masakazu M Fu Yu Y Wong Chi-Huey CH
Journal of the American Chemical Society 20090601 24
A two-step method has been developed to synthesize several biologically important iminocyclitols in ca. 44-60% yields by using Petasis-type condensation. The method is very general and operationally simple, affording a series of iminocyclitols from easily available sugar derivatives. Unexpected diastereoselectivities are observed, suggesting that the condensation may proceed through a five- or six-membered cyclic iminium ion intermediate. ...[more]