Ontology highlight
ABSTRACT:
SUBMITTER: Johnatty SE
PROVIDER: S-EPMC2900295 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Johnatty Sharon E SE Beesley Jonathan J Chen Xiaoqing X Macgregor Stuart S Duffy David L DL Spurdle Amanda B AB deFazio Anna A Gava Natalie N Webb Penelope M PM Rossing Mary Anne MA Doherty Jennifer Anne JA Goodman Marc T MT Lurie Galina G Thompson Pamela J PJ Wilkens Lynne R LR Ness Roberta B RB Moysich Kirsten B KB Chang-Claude Jenny J Wang-Gohrke Shan S Cramer Daniel W DW Terry Kathryn L KL Hankinson Susan E SE Tworoger Shelley S SS Garcia-Closas Montserrat M Yang Hannah H Lissowska Jolanta J Chanock Stephen J SJ Pharoah Paul D PD Song Honglin H Whitemore Alice S AS Pearce Celeste L CL Stram Daniel O DO Wu Anna H AH Pike Malcolm C MC Gayther Simon A SA Ramus Susan J SJ Menon Usha U Gentry-Maharaj Aleksandra A Anton-Culver Hoda H Ziogas Argyrios A Hogdall Estrid E Kjaer Susanne K SK Hogdall Claus C Berchuck Andrew A Schildkraut Joellen M JM Iversen Edwin S ES Moorman Patricia G PG Phelan Catherine M CM Sellers Thomas A TA Cunningham Julie M JM Vierkant Robert A RA Rider David N DN Goode Ellen L EL Haviv Izhak I Chenevix-Trench Georgia G
PLoS genetics 20100708 7
We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleotide polymorphisms (SNPs) in 173 genes involved in stromal epithelial interactions in the Ovarian Cancer Association Consortium (OCAC). In the discovery stage, cases with epithelial ovarian cancer (n=675) and controls (n=1,162) were genotyped a ...[more]