Ontology highlight
ABSTRACT:
SUBMITTER: Garg AK
PROVIDER: S-EPMC7116025 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Garg Amar K AK Desikan Rajat R Dixit Narendra M NM
Cell reports 20191201 12
Passive immunization (PI) with external antibodies has been used classically for rapid but temporary alleviation of disease. Transcending this role, recent studies have shown PI to induce lasting improvements in natural antibody production, suggesting that PI could become a powerful tool to engineer humoral responses. We propose a mechanism with which PI can alter the humoral response. Antigen-specific B cells evolve and get selected in germinal centers (GCs) on the basis of their ability to acq ...[more]