Ontology highlight
ABSTRACT:
SUBMITTER: Xue Y
PROVIDER: S-EPMC2902294 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Xue Yutong Y Li Yongjiang Y Guo Rong R Ling Chen C Wang Weidong W
Human molecular genetics 20080219 11
In response to DNA damage, the Fanconi anemia (FA) core complex functions as a signaling machine for monoubiquitination of FANCD2 and FANCI. It remains unclear whether this complex can also participate in subsequent DNA repair. We have shown previously that the FANCM constituent of the complex contains a highly conserved helicase domain and an associated ATP-dependent DNA translocase activity. Here we show that FANCM also possesses an ATP-independent binding activity and an ATP-dependent bi-dire ...[more]