Ontology highlight
ABSTRACT:
SUBMITTER: Ecker JL
PROVIDER: S-EPMC2904318 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Ecker Jennifer L JL Dumitrescu Olivia N ON Wong Kwoon Y KY Alam Nazia M NM Chen Shih-Kuo SK LeGates Tara T Renna Jordan M JM Prusky Glen T GT Berson David M DM Hattar Samer S
Neuron 20100701 1
Using the photopigment melanopsin, intrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light to drive circadian clock resetting and pupillary constriction. We now report that ipRGCs are more abundant and diverse than previously appreciated, project more widely within the brain, and can support spatial visual perception. A Cre-based melanopsin reporter mouse line revealed at least five subtypes of ipRGCs with distinct morphological and physiological characteristics. C ...[more]