Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt TM
PROVIDER: S-EPMC4083763 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Schmidt Tiffany M TM Alam Nazia M NM Chen Shan S Kofuji Paulo P Li Wei W Prusky Glen T GT Hattar Samer S
Neuron 20140501 4
Distinct subclasses of retinal ganglion cells (RGCs) mediate vision and nonimage-forming functions such as circadian photoentrainment. This distinction stems from studies that ablated melanopsin-expressing intrinsically photosensitive RGCs (ipRGCs) and showed deficits in nonimage-forming behaviors, but not image vision. However, we show that the ON alpha RGC, a conventional RGC type, is intrinsically photosensitive in mammals. In addition to their classical response to fast changes in contrast t ...[more]