Ontology highlight
ABSTRACT:
SUBMITTER: Tang J
PROVIDER: S-EPMC2905049 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Tang Jian J Qian Keduo K Zhang Bei-Na BN Chen Ying Y Xia Peng P Yu Donglei D Xia Yi Y Yang Zheng-Yu ZY Chen Chin-Ho CH Morris-Natschke Susan L SL Lee Kuo-Hsiung KH
Bioorganic & medicinal chemistry 20100429 12
Thirteen novel seco-DCK analogs (4-16) with several new skeletons were designed, synthesized and screened for in vitro anti-HIV-1 activity. Among them, three compounds (5, 13, and 16) showed moderate activity, and compound 9 exhibited the best activity with an EC(50) value of 0.058 microM and a therapeutic index (TI) of 1000. The activity of 9 was better than that of 4-methyl DCK (2, EC(50): 0.126 microM, TI: 301.2) in the same assay. Additionally, 9 also showed antiviral activity against a mult ...[more]