Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC3183312 | biostudies-other | 2011 Oct
REPOSITORIES: biostudies-other
Chen Ying Y Cheng Ming M Liu Fa-Qiang FQ Xia Peng P Qian Keduo K Yu Donglei D Xia Yi Y Yang Zheng-Yu ZY Chen Chin-Ho CH Morris-Natschke Susan L SL Lee Kuo-Hsiung KH
European journal of medicinal chemistry 20110804 10
In a continuing study of novel anti-HIV agents with drug-like structures and properties, 30 1'-O-, 1'-S-, 4'-O- and 4'-substituted-2',3'-seco-3'-nor DCP and DCK analogues (8-37) were designed and synthesized. All newly synthesized seco-compounds were screened against HIV-1(NL4-3) and a multiple reverse transcriptase (RT) inhibitor-resistant (RTMDR) strain in the TZM-bl cell line, using seco-DCK (7) and 2-ethyl-DCP (4) as controls. Several compounds (14, 18, 19, 22-24, and 32) exhibited potent an ...[more]