Electric field-driven disruption of a native beta-sheet protein conformation and generation of a helix-structure.
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ABSTRACT:
SUBMITTER: Ojeda-May P
PROVIDER: S-EPMC2905109 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
Electric field-driven disruption of a native beta-sheet protein conformation and generation of a helix-structure.
Ojeda-May Pedro P Garcia Martin E ME
Biophysical journal 20100701 2
We demonstrate that an external constant electric field is able to modify the secondary structure of a protein and induce a transition from a beta-sheet into a helix-like conformation. This dramatic change is driven by a global rearrangement of the dipole moments at the amide planes. We also predict electric-field-induced modifications of the intermediate states of the protein. ...[more]
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