Ontology highlight
ABSTRACT:
SUBMITTER: Dovas A
PROVIDER: S-EPMC2906322 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Dovas Athanassios A Choi Youngsil Y Yoneda Atsuko A Multhaupt Hinke A B HA Kwon Seung-Hae SH Kang Dongmin D Oh Eok-Soo ES Couchman John R JR
The Journal of biological chemistry 20100515 30
Conventional protein kinase C (PKC) isoforms are essential serine/threonine kinases regulating many signaling networks. At cell adhesion sites, PKCalpha can impact the actin cytoskeleton through its influence on RhoGTPases, but the intermediate steps are not well known. One important regulator of RhoGTPase function is the multifunctional guanine nucleotide dissociation inhibitor RhoGDIalpha that sequesters several related RhoGTPases in an inactive form, but it may also target them through intera ...[more]