Ontology highlight
ABSTRACT:
SUBMITTER: Shi GX
PROVIDER: S-EPMC5777029 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Shi Geng-Xian GX Yang Won Seok WS Jin Ling L Matter Michelle L ML Ramos Joe W JW
Proceedings of the National Academy of Sciences of the United States of America 20171226 2
Directed migration is essential for cell motility in many processes, including development and cancer cell invasion. RSKs (p90 ribosomal S6 kinases) have emerged as central regulators of cell migration; however, the mechanisms mediating RSK-dependent motility remain incompletely understood. We have identified a unique signaling mechanism by which RSK2 promotes cell motility through leukemia-associated RhoGEF (LARG)-dependent Rho GTPase activation. RSK2 directly interacts with LARG and nucleotide ...[more]