Elevated expression of RNA methyltransferase BCDIN3D predicts poor prognosis in breast cancer.
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ABSTRACT: Background
BCDIN3D is a member of the Bin3 methyl-transferase family that targets the 5' mono-phosphate of nucleic acids. Although BCDIN3D has been shown to increase tumorigenic phenotypes and invasiveness in MDA-MB-231 cells, its the clinical implications in breast cancer remain unclear.Methods
We screened for BCDIN3D using tissue microarrays constructed from 250 patients who were histologically confirmed to have invasive ductal breast carcinoma at the Fudan University Shanghai Cancer Center.Results
The survival analysis by Kaplan-Meier and Cox regression showed that BCDIN3D expression level served as a prognostic factor for disease-free survival (P = 0.042). The prognostic value of BCDIN3D was most significant in triple-negative breast cancer (TNBC) patients (P = 0.007).Conclusions
BCDIN3D might serve as an important prognostic factor for TNBC patients.
SUBMITTER: Yao L
PROVIDER: S-EPMC5288229 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Elevated expression of RNA methyltransferase BCDIN3D predicts poor prognosis in breast cancer.
Yao Ling L Chi Yayun Y Hu Xin X Li Shan S Qiao Feng F Wu Jong J Shao Zhi-Ming ZM
Oncotarget 20160801 33
<h4>Background</h4>BCDIN3D is a member of the Bin3 methyl-transferase family that targets the 5' mono-phosphate of nucleic acids. Although BCDIN3D has been shown to increase tumorigenic phenotypes and invasiveness in MDA-MB-231 cells, its the clinical implications in breast cancer remain unclear.<h4>Methods</h4>We screened for BCDIN3D using tissue microarrays constructed from 250 patients who were histologically confirmed to have invasive ductal breast carcinoma at the Fudan University Shanghai ...[more]
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