Ontology highlight
ABSTRACT: Abbreviations
NFE2L3: NF-E2-related factor 3; UHMK1: U2AF homology motif kinase 1; VEGFA: vascular endothelial growth factor A; GEO: gene expression omnibus; TCGA: The Cancer Genome Atlas; HPDE: human pancreas duct cells; OS: overall survival; IHC: immunohistochemistry; FFPE: formalin-fixed and paraffin-embedded; SEM: standard error of mean.
SUBMITTER: Wang H
PROVIDER: S-EPMC6226237 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Wang Hui H Zhan Ming M Yang Ruimeng R Shi Yongheng Y Liu Qiang Q Wang Jian J
Cell cycle (Georgetown, Tex.) 20180922 17
The highly malignant feature and difficulties for early diagnosis are the key reasons contributing to the poor prognosis of pancreatic cancer (PC) patients. NFE2L3 is a nuclear transcription factor, which has been reported an important biomarker of several tumors. But the role of NFE2L3 in PC remained undefined. Herein, through qPCR and immunohistochemistry, we found a significantly increased NFE2L3 in PC tissues as compared with adjacent non-tumor tissues. While reducing NFE2L3 expression suppr ...[more]