Unknown

Dataset Information

0

Coffee consumption, genetic susceptibility and bladder cancer risk.


ABSTRACT: OBJECTIVE:We evaluated the bladder cancer risk associated with coffee consumption in a case-control study in Spain and examined the gene-environment interactions for genetic variants of caffeine-metabolizing enzymes. METHODS:The analyses included 1,136 incident cases with urothelial carcinoma of the urinary bladder and 1,138 controls. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for area, age, gender, amount of cigarette smoking, and years since quitting among former smokers. RESULTS:The OR (95% CI) for ever consumed coffee was 1.25 (0.95-1.64). For consumers of 1, 2, 3, and 4 or more cups/day relative to never drinkers, OR were, respectively, 1.24 (0.92-1.66), 1.11 (95% CI 0.82-1.51), 1.57 (1.13-2.19), and 1.27 (0.88-1.81). Coffee consumption was higher in smokers compared to never smokers. The OR for drinking at least 4 cups/day was 1.13 (0.61-2.09) in current smokers, 1.57 (0.86-2.90) in former smokers, and 1.23 (0.55-2.76) in never smokers. Gene-coffee interactions evaluated in NAT2, CYP1A2, and CYP2E1-02 and CYP1A1 were not identified after adjusting for multiple testing. CONCLUSION:We observed a modest increased bladder cancer risk among coffee drinkers that may, in part, be explained by residual confounding by smoking. The findings from the gene-coffee interactions need replication in further studies.

SUBMITTER: Villanueva CM 

PROVIDER: S-EPMC2912840 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications


<h4>Objective</h4>We evaluated the bladder cancer risk associated with coffee consumption in a case-control study in Spain and examined the gene-environment interactions for genetic variants of caffeine-metabolizing enzymes.<h4>Methods</h4>The analyses included 1,136 incident cases with urothelial carcinoma of the urinary bladder and 1,138 controls. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for area, age, gender, amount of cigarette smoking, and years since quitting among  ...[more]

Similar Datasets

| S-EPMC3172962 | biostudies-literature
| S-EPMC4356958 | biostudies-literature
| S-EPMC6743122 | biostudies-literature
| S-EPMC4874555 | biostudies-literature
| S-EPMC3664723 | biostudies-literature
| S-EPMC3218935 | biostudies-literature
| S-EPMC5929300 | biostudies-literature
| S-EPMC3220186 | biostudies-literature
| S-EPMC5765424 | biostudies-literature
| S-EPMC7815134 | biostudies-literature