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Mechanistic origin of the stereodivergence in decarboxylative allylation.

ABSTRACT: A stereochemical test has been used to probe the mechanism of decarboxylative allylation. This probe suggests that the mechanism of DcA reactions can change based on the substitution pattern at the alpha-carbon of the nucleophile; however, reaction via stabilized malonate nucleophiles is the lower energy pathway. Lastly, this mechanistic proposal has predictive power and can be used to explain chemoselectivities in decarboxylative reactions that were previously confounding.

SUBMITTER: Chattopadhyay K

PROVIDER: S-EPMC2913676 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Mechanistic origin of the stereodivergence in decarboxylative allylation.

Chattopadhyay Kalicharan K Jana Ranjan R Day Victor W VW Douglas Justin T JT Tunge Jon A JA

Organic letters 20100701 13

A stereochemical test has been used to probe the mechanism of decarboxylative allylation. This probe suggests that the mechanism of DcA reactions can change based on the substitution pattern at the alpha-carbon of the nucleophile; however, reaction via stabilized malonate nucleophiles is the lower energy pathway. Lastly, this mechanistic proposal has predictive power and can be used to explain chemoselectivities in decarboxylative reactions that were previously confounding. ...[more]

PMID: 20533852

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