Ontology highlight
ABSTRACT:
SUBMITTER: Recio A
PROVIDER: S-EPMC2794903 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Organic letters 20091201 24
Palladium-catalyzed decarboxylative alpha-allylation of nitriles readily occurs with use of Pd(2)(dba)(3) and rac-BINAP. This catalyst mixture also allows the highly regiospecific alpha-allylation of nitriles in the presence of much more acidic alpha-protons. Thus, the reported method provides access to compounds that are not readily available via base-mediated allylation chemistries. Lastly, mechanistic investigations indicate that there is a competition between C- and N-allylation of an interm ...[more]