Tailoring to RB: tumour suppressor status and therapeutic response.
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ABSTRACT:
SUBMITTER: Knudsen ES
PROVIDER: S-EPMC2914856 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
Tailoring to RB: tumour suppressor status and therapeutic response.
Knudsen Erik S ES Knudsen Karen E KE
Nature reviews. Cancer 20080901 9
The retinoblastoma tumour suppressor (RB) is a crucial regulator of cell-cycle progression that is invoked in response to a myriad of anti-mitogenic signals. It has been hypothesized that perturbations of the RB pathway confer a synonymous proliferative advantage to tumour cells; however, recent findings demonstrate context-specific outcomes associated with such lesions. Particularly, loss of RB function is associated with differential response to wide-ranging therapeutic agents. Thus, the statu ...[more]
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