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N-(3,4-Dimethyl-phen-yl)acetamide.

ABSTRACT: The conformation of the N-H bond in the title compound (34DMPA), C(10)H(13)NO, is syn to the 3-methyl substituent in the aromatic ring, in contrast to the anti conformation observed with respect to the 3-chloro substituent in N-(3,4-dichloro-phen-yl)acetamide (34DCPA). The asymmetric unit of the structure contains three mol-ecules. The bond parameters in 34DMPA are similar to those in 34DCPA, N-(2,6-dimethyl-phen-yl)acetamide, N-(3,5-dimethyl-phen-yl)acetamide and other acetanilides. The mol-ecules in 34DMPA are linked into infinite chains through N-H⋯O hydrogen bonding.

SUBMITTER: Gowda BT

PROVIDER: S-EPMC2914973 | biostudies-literature |

REPOSITORIES: biostudies-literature

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N-{4-[(3,4-Dimethyl-phen-yl)sulfamo-yl]phen-yl}acetamide.

Project description:Two independent mol-ecules comprise the asymmetric unit of the title compound, C(16)H(18)N(2)O(3)S. Small but significant twists about the (S)N-C and S-C bonds differentiate the mol-ecules but the most obvious difference is found in the relative orientation of the meta-methyl groups, which lie on opposite sides of the mol-ecules. Overall, both mol-ecules adopt a U shape but with significant twisting evident, particularly in the second independent mol-ecule [dihedral angles between benzene rings = 63.90?(13) and 35.78?(11)°]. In the crystal, N-H?O hydrogen bonds lead to supra-molecular chains with a tubular topology propagating in [100] and C-H?O contacts cross-link the chains.

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2,2-Dichloro-N-(3,4-dimethyl-phen-yl)acetamide.

Project description:In the title compound, C(10)H(11)Cl(2)NO, the N-H bond is syn to the 3-methyl substituent in the aromatic ring, similar to that observed in N-(3,4-dimethyl-phen-yl)acetamide and to the 3-chloro substituent in 2,2-dichloro-N-(3,4-dichloro-phen-yl)acetamide, and contrasting with the anti conformation observed for the 3-methyl substituent in 2,2,2-trichloro-N-(3,4-dimethyl-phen-yl)acetamide. On the other hand, it is anti to the C=O bond. An inter-molecular N-H?O hydrogen bond links mol-ecules into infinite chains along the b axis.

| S-EPMC2969347 | biostudies-literature

2-Chloro-N-(3,4-dimethyl-phen-yl)acetamide.

Project description:The conformation of the C=O bond in the structure of the title compound, C(10)H(12)ClNO, is anti to the N-H bond and to the methyl-ene H atoms in the side chain in both the independent mol-ecules comprising the asymmetric unit. However, the conformation of the N-H bond is syn to the meta-methyl substituent in the aromatic ring of one of the mol-ecules and anti in the other mol-ecule. The two independent mol-ecules are linked through inter-molecular N-H?O hydrogen bonding into chains parallel to the b axis.

| S-EPMC2977707 | biostudies-literature

2,2,2-Trichloro-N-(3,4-dimethyl-phen-yl)acetamide.

Project description:The conformation of the N-H bond in the title compound, C(10)H(10)Cl(3)NO, is anti to the C=O bond. The amide H atom exhibits both intra-molecular N-H?Cl and inter-molecular N-H?O hydrogen bonding. The latter inter-actions link the mol-ecules into infinite chains.

| S-EPMC2977724 | biostudies-literature

N-{4-[(3,4-Dimethyl-phen-yl)(eth-yl)sulfamo-yl]phen-yl}-N-ethyl-acetamide.

Project description:When viewed down the central S?N axis of the title compound, C(20)H(26)N(2)O(3)S, it is apparent that the mol-ecule adopts a gauche conformation with all O atoms lying to one side of the central benzene ring; the carbonyl O atom is directed away from the central ring and the N-bound ethyl groups lie to one side of the mol-ecule. Supra-molecular helical chains aligned along the b axis and sustained by C-H?O contacts feature in the crystal packing. These are consolidated in the three-dimensional structure by C-H?? inter-actions.

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N-(3,4-Diethoxy-phen-yl)acetamide.

Project description:In the title compound, C(12)H(17)NO(3), the conformations of the N-H and C=O bonds are anti to each other. In the crystal structure, N-H?O hydrogen-bond inter-actions help to establish the packing.

| S-EPMC2969794 | biostudies-literature

N-(2,3-Dimethyl-phen-yl)acetamide.

Project description:The conformation of the N-H bond in the structure of the title compound, C(10)H(13)NO, is syn to both the 2- and 3-methyl substituents on the aromatic ring, and is anti to the C=O bond. N-H?O hydrogen bonds link the mol-ecules into supra-molecular chains.

| S-EPMC2977664 | biostudies-literature

(2-Benzoyl-phen-yl)(3,4-dimethyl-phen-yl)methanone.

Project description:In the title compound, C(22)H(18)O(2), the central benzene ring forms dihedral angles of 76.0?(1) and 73.1?(1)° with the phenyl ring and dimethyl-substituted benzene ring, respectively. The carbonyl-group O atoms deviate significantly from the phenyl ring and the dimethyl-substituted benzene ring [-0.582?(12) and 0.546?(12)?Å, respectively]. The crystal packing is stabilized by C-H?? inter-actions.

| S-EPMC3213611 | biostudies-literature

2-(4-Bromo-phen-yl)-N-(3,4-di-fluoro-phen-yl)acetamide.

Project description:In the title compound, C14H10BrF2NO, the dihedral angle between the mean planes of the 4-bromo-phenyl and 3,4-di-fluoro-phenyl rings is 66.4?(1)°. These two planes are twisted by 40.0?(5) and 86.3?(2)°, respectively, from that of the acetamide group. In the crystal, N-H?O hydrogen bonds and weak C-H?O and C-H?F inter-actions form infinite chains along [100].

| S-EPMC3685057 | biostudies-literature

2-(4-Bromo-phen-yl)-N-(2,6-dimethyl-phen-yl)acetamide.

Project description:In the title compound, C(16)H(16)BrNO, the dihedral angle between the benzene rings is 69.8?(2)°. In the crystal, N-H?O hydrogen bonds link the mol-ecules into C(4) chains propagating in [100]. Adjacent mol-ecules in the chains are also linked by C-H?O inter-actions which, along with the N-H?O hydrogen bonds, generate R(2) (1)(6) loops.

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