Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC2916442 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20100614 16
Epac1 (exchange protein directly activated by cyclic AMP [cAMP]) couples intracellular cAMP to the activation of Rap1, a Ras family GTPase that regulates cell adhesion, proliferation, and differentiation. Using mass spectrometry, we identified the small G protein Ran and Ran binding protein 2 (RanBP2) as potential binding partners of Epac1. Ran is a small G protein best known for its role in nuclear transport and can be found at the nuclear pore through its interaction with RanBP2. Here we demon ...[more]