Ontology highlight
ABSTRACT:
SUBMITTER: Ma D
PROVIDER: S-EPMC2918410 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Ma Deqiong D Salyakina Daria D Jaworski James M JM Konidari Ioanna I Whitehead Patrice L PL Andersen Ashley N AN Hoffman Joshua D JD Slifer Susan H SH Hedges Dale J DJ Cukier Holly N HN Griswold Anthony J AJ McCauley Jacob L JL Beecham Gary W GW Wright Harry H HH Abramson Ruth K RK Martin Eden R ER Hussman John P JP Gilbert John R JR Cuccaro Michael L ML Haines Jonathan L JL Pericak-Vance Margaret A MA
Annals of human genetics 20090501 Pt 3
Although autism is one of the most heritable neuropsychiatric disorders, its underlying genetic architecture has largely eluded description. To comprehensively examine the hypothesis that common variation is important in autism, we performed a genome-wide association study (GWAS) using a discovery dataset of 438 autistic Caucasian families and the Illumina Human 1M beadchip. 96 single nucleotide polymorphisms (SNPs) demonstrated strong association with autism risk (p-value < 0.0001). The validat ...[more]